Raman Spectroscopy with Real Fluorescence Rejection
Is fluorescence hindering your Raman analysis?
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Fluorescence hindering your Raman analysis?
The ‘Achilles’ heel’ of conventional Raman technology is photoluminescence (including fluorescence, phosphorescence etc.). Photoluminescence is a competing phenomenon with Raman scattering which can mask the whole Raman signal in the measured spectra, making the identification and quantification of materials impossible.
With Timegate’s new technology, we can now achieve real fluorescence rejection.
With the Timegate PicoRaman you can:
- Minimize fluorescence, maximize Raman signal
- Monitor molecular interactions in the pico- and nanosecond time range
- Optimize signal-to-noise by capturing any slice of the time-resolved Raman signal
- The TimeGated® PicoRaman enables successful Raman analysis in subjects such as biology and geoscience where previously, the fluorescence emission hindered proper analysis.
- Increase product yields in biopharmaceutical manufacturing
- Identify polymorphs of pharmaceutical solids
- Identify mineralolgical components in ores for mining applications.
These are just a few of the many possible applications – contact us today to discuss your Timegated® Raman application!
How do we do this?
A patented combination of a sub-nanosecond (100 ps) laser excitation source and time-gated single photon counting array detector creates a totally new type of spectrometer able to acquire Raman spectra with real fluorescence rejection. The prompt Raman signal is acquired before significant fluorescence occurs. It also enables the acquisition of time-resolved fluorescence spectra by sequentially sampling the emission pulses at different temporal positions. This approach opens up two simultaneous windows for material characterization and gives valuable new information in several different application fields.
Apart from molecular structure information from Raman spectra, Timegated® technology can be used for time-resolved fluorescence spectroscopic applications to monitor molecular interactions and motions that occur in the picosecond-nanosecond range.
Timegate, headquarted in Finland, developed a Raman spectrometer that achieves true fluorescence rejection. Minimize fluorescence, maximize Raman signal.
To learn more about Timegate visit https://www.timegate.com/